1 in 38 Americans are symptomless carriers of cystic fibrosis—an inherited, life-threatening condition affecting the lungs, pancreas, and other organs.1,2
Cystic fibrosis (CF) is the most common life-threatening autosomal recessive condition in the non-Hispanic white population. It is a progressive, multisystem disease that primarily affects the pulmonary, pancreatic, and gastrointestinal systems. CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR ) gene. When both parents are carriers of a mutation in this gene, they have a 1 in 4 chance of having a child with CF.2
ACOG and ACMG recommend offering CF carrier screening to all patients, regardless of ethnicity.2,4
Screening results inform patients of their carrier status and can help guide decision-making for patients who are pregnant, planning a pregnancy, or considering fertility options.